Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia: Innocent or Guilty?

ABSTRACT: The outcome of allogeneic hematopoietic cell transplantation (allo-HCT) largely depends on the development and management of graft-versus-host disease (GvHD), infections, and the occurrence of relapse of malignancies. Recent studies showed a lower incidence of chronic GvHD and severe acute GvHD in patients receiving naive T cell depleted grafts compared to patients receiving complete T cell depleted grafts. On the other hand, the incidence of acute GvHD in patients receiving cord blood grafts containing only naive T cells is rather low, while potent graft-versus-leukemia (GvL) responses have been observed. These data suggest the significance of naive T cells as both drivers and regulators of allogeneic reactions. The naive T cell pool was previously thought to be a quiescent, homogenous po

SUBMITTER: Dekker L 

PROVIDER: S-EPMC9250980 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature