Ontology highlight
ABSTRACT:
SUBMITTER: Triboulet S
PROVIDER: S-EPMC9251005 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Triboulet Sébastien S N'Gadjaga Maimouna D MD Niragire Béatrice B Köstlbacher Stephan S Horn Matthias M Aimanianda Vishukumar V Subtil Agathe A
Frontiers in cellular and infection microbiology 20220620
The obligate intracellular bacteria <i>Chlamydia trachomatis</i> store glycogen in the lumen of the vacuoles in which they grow. Glycogen catabolism generates glucose-1-phosphate (Glc1P), while the bacteria can take up only glucose-6-phosphate (Glc6P). We tested whether the conversion of Glc1P into Glc6P could be catalyzed by a phosphoglucomutase (PGM) of host or bacterial origin. We found no evidence for the presence of the host PGM in the vacuole. Two <i>C. trachomatis</i> proteins, CT295 and ...[more]