Ontology highlight
ABSTRACT:
SUBMITTER: Gara E
PROVIDER: S-EPMC9254250 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Gara Edit E Zucchelli Eleonora E Nemes Annamária A Jakus Zoltán Z Ajtay Kitti K Kemecsei Éva É Kiszler Gábor G Hegedűs Nikolett N Szigeti Krisztián K Földes Iván I Árvai Kristóf K Kósa János J Kolev Kraszimir K Komorowicz Erzsébet E Padmanabhan Parasuraman P Maurovich-Horvat Pál P Dósa Edit E Várady György G Pólos Miklós M Hartyánszky István I Harding Sian E SE Merkely Béla B Máthé Domokos D Szabó Gábor G Radovits Tamás T Földes Gábor G
Theranostics 20220606 10
<b>Rationale:</b> Human induced pluripotent stem cell-derived endothelial cells can be candidates for engineering therapeutic vascular grafts. <b>Methods:</b> Here, we studied the role of three-dimensional culture on their characteristics and function both <i>in vitro</i> and <i>in vivo</i>. <b>Results:</b> We found that differentiated hPSC-EC can re-populate decellularized biomatrices; they remain viable, undergo maturation and arterial/venous specification. Human PSC-EC develop antifibrotic, v ...[more]