Ontology highlight
ABSTRACT:
SUBMITTER: Peng Z
PROVIDER: S-EPMC9254453 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Peng Zhouyangfan Z Duan Mingwu M Tang Yiting Y Wu Jianfeng J Zhao Kai K Zhong Yanjun Y He Zhihui Z Meng Jie J Chen Fangping F Xiao Xianzhong X Wang Haichao H Billiar Timothy R TR Lu Ben B Liang Fang F
iScience 20220619 7
Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility. Single-cell sequencing of bronchoalveolar lavage fluid cells of mine workers with silicosis and their co-workers who did not develop silicosis revealed that the impaired interferon (IFN)-γ signaling in myeloid cells was strongly associated with the occurrence of silicosis. G ...[more]