Browse
Submit Data
Databases
API
Help

Dataset Information

10 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

IGF1 receptor-targeted black TiO₂ nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignant tumors with features of matrix barrier caused poor drug permeability, and susceptibility to drug resistance. Herein, a PDAC and its stromal cell dual-targeted photothermal-chemotherapy strategy is explored to loosen the matrix and reverse drug resistance. To achieve this goal, black TiO₂-Gd nanocomposites were conjugated with insulin like growth factor 1 (IGF1), and loaded with gemcitabine (GEM) to construct bTiO₂-Gd-IGF1-GEM nanoprobes. In vitro results show that under 808 nm near-infrared irradiation, killing effect of the nanoprobes on drug-resistant MIA PaCa-2 cell is 3.3 times than that of GEM alone. In vivo experiments indicate the synergetic photothermal-chemotherapy not only loosens fibrous matrix of pancreatic tumor model, but also dramatically inhibits tumor growth, and almost completely eradicates the tumor after 12 days of treatment. In addition, relaxation rate of the nanoprobes is 8.2 times than commercial contrast agent Magnevist, therefore boosts the signal of magnetic resonance imaging in pancreatic tumor. In conclusion, our results reinforce that the prepared nanoprobes are promising to break matrix barrier and overcome drug resistance in PDAC.

SUBMITTER: Xu K

PROVIDER: S-EPMC9258211 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Hyperthermia-Triggered On-Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy.

Project description:Nanoparticle-based drug delivery systems with low side effects and enhanced efficacy hold great potential in the treatment of various malignancies, in particular cancer; however, they are still challenging to attain. Herein, an anticancer drug delivery system based on a cisplatin (CDDP) containing nanogel, functionalized with photothermal gold nanorods (GNRs) which are electrostatically decorated with doxorubicin (DOX) is reported. The nanoparticles are formed via the crosslinking reaction of hyaluronic acid with the ancillary anticarcinogen CDDP in the presence of DOX-decorated GNRs. The nanogel is furthermore cloaked with a cancer cell membrane, and the resulting biomimetic nanocarrier (4T1-HANG-GNR-DC) shows efficient accumulation by homologous tumor targeting and possesses long-time retention in the tumor microenvironment. Upon near-infrared (NIR) laser irradiation, in situ photothermal therapy is conducted which further induces hyperthermia-triggered on-demand drug release from the nanogel reservoir to achieve a synergistic photothermal/chemo-therapy. The as-developed biomimetic nanocarriers, with their dual-drug delivery features, homotypic tumor targeting and synergetic photothermal/chemo-therapy, show much promise as a potential platform for cancer treatment.

| S-EPMC7284223 | biostudies-literature

Designing highly stable ferrous selenide-black phosphorus nanosheets heteronanostructure via P-Se bond for MRI-guided photothermal therapy.

Project description:BackgroundThe design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is imminent.ResultsHerein, black phosphorus nanosheets (BPs) covalently with mono-dispersed and superparamagnetic ferrous selenide (FeSe2) to construct heteronanostructure nanoparticles modified with methoxy poly (Ethylene Glycol) (mPEG-NH2) to obtain good water solubility for MRI-guided photothermal tumor therapy is successfully designed. The mechanism reveals that the enhanced photothermal conversion achieved by BPs-FeSe2-PEG heteronanostructure is attributed to the effective separation of photoinduced carriers. Besides, through the formation of the P-Se bond, the oxidation degree of FeSe2 is weakened. The lone pair electrons on the surface of BPs are occupied, which reduces the exposure of lone pair electrons in air, leading to excellent stability of BPs-FeSe2-PEG. Furthermore, the BPs-FeSe2-PEG heteronanostructure could realize enhanced T2-weighted imaging due to the aggregation of FeSe2 on BPs and the formation of hydrogen bonds, thus providing accurate PTT guidance and generating hyperthermia to inhabit tumor growth under NIR laser with negligible toxicity in vivo.ConclusionsCollectively, this work offers an opportunity for fabricating BPs-based heteronanostructure nanomaterials that could simultaneously enhance photothermal conversion efficiency and photostability to realize MRI-guided cancer therapy.

| S-EPMC8262019 | biostudies-literature

Fe3O4@SiO2@Au nanoparticles for MRI-guided chemo/NIR photothermal therapy of cancer cells.

Project description:Novel functionalized (biofunctionalization followed by cisplatin immobilization) Fe3O4@SiO2@Au nanoparticles (NPs) were designed. The encapsulation of Fe3O4 cores inside continuous SiO2 shells preserves their initial structure and strong magnetic properties, while the shell surface can be decorated by small Au NPs, and then cisplatin (cPt) can be successfully immobilized on their surface. The fabricated NPs exhibit very strong T 2 contrasting properties for magnetic resonance imaging (MRI). The functionalized Fe3O4@SiO2@Au NPs are tested for a potential application in photothermal cancer therapy, which is simulated by irradiation of two colon cancer cell lines (SW480 and SW620) with a laser (λ = 808 nm, W = 100 mW cm-2). It is found that the functionalized NPs possess low toxicity towards cancer cells (∼10-15%), which however could be drastically increased by laser irradiation, leading to a mortality of the cells of ∼43-50%. This increase of the cytotoxic properties of the Fe3O4@SiO2@Au NPs, due to the synergic effect between the presence of cPt plus Au NPs and laser irradiation, makes these NPs perspective agents for potential (MRI)-guided stimulated chemo-photothermal treatment of cancer.

| S-EPMC9055504 | biostudies-literature

Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes.

Project description:Lymph node metastasis is a major metastatic route of cancer and significantly influences the prognosis of cancer patients. Radical lymphadenectomy is crucial for a successful surgery. However, iatrogenic normal organ injury during lymphadenectomy is a troublesome complication. Here, this paper reports a kind of organic nanoprobes (IDSe-IC2F nanoparticles (NPs)) with excellent second near-infrared (NIR-II) fluorescence and photothermal properties. IDSe-IC2F NPs can effectively label lymph nodes and helped achieve high-contrast lymphatic imaging. More importantly, by jointly using IDSe-IC2F nanoparticles and other kinds of nanoparticles with different excitation/emission properties, a multichannel NIR-II fluorescence imaging modality and imaging-guided lymphadenectomy is proposed. With the help of this navigation system, the iatrogenic injury can be largely avoided. In addition, NIR-II fluorescence imaging-guided photothermal treatment ("hot" strategy) can ablate those metastatic lymph nodes which are difficult to deal with during resection ("cold" strategy). Nanoprobes-assisted and multichannel NIR-II fluorescence imaging-guided "cold" and "hot" treatment strategy provides a general new basis for the future precision surgery.

| S-EPMC8097375 | biostudies-literature

Targeted co-delivery of curcumin and erlotinib by MoS2 nanosheets for the combination of synergetic chemotherapy and photothermal therapy of lung cancer.

Project description:BackgroundCurcumin (Cur), a bioactive component of Chinese traditional medicine, has demonstrated inhibitory properties against cancer cell proliferation while synergistically enhancing the anticancer efficacy of erlotinib (Er). However, the individual limitations of both drugs, including poor aqueous solubility, lack of targeting ability, short half-life, etc., and their distinct pharmacokinetic profiles mitigate or eliminate their combined antitumor potential.ResultsIn this study, we developed a molybdenum disulfide (MoS2)-based delivery system, functionalized with polyethylene glycol (PEG) and biotin, and co-loaded with Cur and Er, to achieve efficient cancer therapy. The MoS2-PEG-Biotin-Cur/Er system effectively converted near-infrared (NIR) light into heat, thereby inducing direct photothermal ablation of cancer cells and promoting controlled release of Cur and Er. Biotin-mediated tumor targeting facilitated the selective accumulation of MoS2-PEG-Biotin-Cur/Er at the tumor site, thus enhancing the synergistic antitumor effects of Cur and Er. Remarkably, MoS2-PEG-Biotin-Cur/Er achieved the combination of synergistic chemotherapy and photothermal therapy (PTT) upon NIR irradiation, effectively suppressing lung cancer cell proliferation and inhabiting tumor growth in vivo.ConclusionsThe as-synthesized MoS2-PEG-Biotin-Cur/Er, featuring high targeting ability, NIR light-responsive drug release, and the integration of synergistic chemotherapy and PTT, may provide a promising strategy for the treatment of lung cancer in clinical practice.

| S-EPMC10505307 | biostudies-literature

Enhanced Solar Photothermal Catalysis over Solution Plasma Activated TiO2.

Project description:Colored wide-bandgap semiconductor oxides with abundant mid-gap states have long been regarded as promising visible light responsive photocatalysts. However, their catalytic activities are hampered by charge recombination at deep level defects, which constitutes the critical challenge to practical applications of these oxide photocatalysts. To address the challenge, a strategy is proposed here that includes creating shallow-level defects above the deep-level defects and thermal activating the migration of trapped electrons out of the deep-level defects via these shallow defects. A simple and scalable solution plasma processing (SPP) technique is developed to process the presynthesized yellow TiO2 with numerous oxygen vacancies (Ov), which incorporates hydrogen dopants into the TiO2 lattice and creates shallow-level defects above deep level of Ov, meanwhile retaining the original visible absorption of the colored TiO2. At elevated temperature, the SPP-treated TiO2 exhibits a 300 times higher conversion rate for CO2 reduction under solar light irradiation and a 7.5 times higher removal rate of acetaldehyde under UV light irradiation, suggesting the effectiveness of the proposed strategy to enhance the photoactivity of colored wide-bandgap oxides for energy and environmental applications.

| S-EPMC7435248 | biostudies-literature

The Superiority of TiO2 Supported on Nickel Foam over Ni-Doped TiO2 in the Photothermal Decomposition of Acetaldehyde.

Project description:Acetaldehyde decomposition was performed under heating at a temperature range of 25-125 °C and UV irradiation on TiO2 doped by metallic Ni powder and TiO2 supported on nickel foam. The process was carried out in a high-temperature reaction chamber, "The Praying MantisTM", with simultaneous in situ FTIR measurements and UV irradiation. Ni powder was added to TiO2 in the quantity of 0.5 to 5.0 wt%. The photothermal measurements of acetaldehyde decomposition indicated that the highest yield of acetaldehyde conversion on TiO2 and UV irradiation was obtained at 75 °C. The doping of nickel to TiO2 did not increase its photocatalytic activity. Contrary to that, the application of nickel foam as a support for TiO2 appeared to be highly advantageous because it increased the decomposition of acetaldehyde from 31 to 52% at 25 °C, and then to 85% at 100 °C in comparison with TiO2 itself. At the same time, the mineralization of acetaldehyde to CO2 doubled in the presence of nickel foam. However, oxidized nickel foam used as support for TiO2 was detrimental. Most likely, different mechanisms of electron transfer between Ni-TiO2 and NiO-TiO2 occurred. The application of nickel foam greatly enhanced the separation of free carriers in TiO2. As a consequence, high yields from the photocatalytic reactions were obtained.

| S-EPMC10420295 | biostudies-literature

Diversity of TiO2: Controlling the Molecular and Electronic Structure of Atomic-Layer-Deposited Black TiO2.

Project description:Visually black, electrically leaky, amorphous titania (am-TiO2) thin films were grown by atomic layer deposition (ALD) for photocatalytic applications. Broad spectral absorbance in the visible range and exceptional conductivity are attributed to trapped Ti3+ in the film. Oxidation of Ti3+ upon heat treatment leads to a drop in conductivity, a color change from black to white, and crystallization of am-TiO2. ALD-grown black TiO2, without any heat treatment, is subject to dissolution in alkaline photoelectrochemical conditions. The best photocatalytic activity for solar water splitting is obtained for completely crystalline white TiO2.

| S-EPMC6727370 | biostudies-literature

Construction of Bio-TiO2/Algae Complex and Synergetic Mechanism of the Acceleration of Phenol Biodegradation.

Project description:Microalgae have been widely employed in water pollution treatment since they are eco-friendly and economical. However, the relatively slow treatment rate and low toxic tolerance have seriously limited their utilization in numerous conditions. In light of the problems above, a novel biosynthetic titanium dioxide (bio-TiO2 NPs)-microalgae synergetic system (Bio-TiO2/Algae complex) has been established and adopted for phenol degradation in the study. The great biocompatibility of bio-TiO2 NPs ensured the collaboration with microalgae, improving the phenol degradation rate by 2.27 times compared to that with single microalgae. Remarkably, this system increased the toxicity tolerance of microalgae, represented as promoted extracellular polymeric substances EPS secretion (5.79 times than single algae), and significantly reduced the levels of malondialdehyde and superoxide dismutase. The boosted phenol biodegradation with Bio-TiO2/Algae complex may be attributed to the synergetic interaction of bio-TiO2 NPs and microalgae, which led to the decreased bandgap, suppressed recombination rate, and accelerated electron transfer (showed as low electron transfer resistance, larger capacitance, and higher exchange current density), resulting in increased light energy utilization rate and photocatalytic rate. The results of the work provide a new understanding of the low-carbon treatment of toxic organic wastewater and lay a foundation for further remediation application.

| S-EPMC10221352 | biostudies-literature

CuGeO3 Nanoparticles: An Efficient Photothermal Theragnosis Agent for CT Imaging-Guided Photothermal Therapy of Cancers.

Project description:The photothermal agents have been widely developed due to the minimally invasive treatment for targeted tumor photothermal therapy, which is considered to have great potential for antitumor bioapplications. The development of multifunctional photothermal agents is extremely challenging. This work presents a novel photothermal theragnosis agent, i.e., CuGeO3 nanoparticles (CGO NPs), showing intense absorption in the near-infrared (NIR) window and excellent ability of CT imaging. Due to the strong NIR absorption, CGO NPs exhibit excellent photothermal effect with a photothermal conversion efficiency of 59.4%. Moreover, because of the high X-ray attenuation coefficient of germanium, the CGO NPs have a great potential of CT imaging diagnosis in clinical application. Additionally, the CGO NPs show negligible cytotoxicity in vitro and in vivo, indicating that it can be served as an outstanding contrast and anticancer agent in a biosafe way. Our work opens the way for the development of bimetallic copper-based oxides used in photothermal diagnostic agents for cancer treatment.

| S-EPMC7717952 | biostudies-literature