Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration.
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ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC9259589 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration.
Kim Hyunho H Hong Sung-Hee SH Jeong Hyo Eun HE Han Sewoon S Ahn Jinchul J Kim Jin-A JA Yang Ji-Hun JH Oh Hyun Jeong HJ Chung Seok S Lee Sang-Eun SE
Scientific reports 20220706 1
The protozoan parasite Toxoplasma gondii (T. gondii) causes one of the most common human zoonotic diseases and infects approximately one-third of the global population. T. gondii infects nearly every cell type and causes severe symptoms in susceptible populations. In previous laboratory animal studies, T. gondii movement and transmission were not analyzed in real time. In a three-dimensional (3D) microfluidic assay, we successfully supported the complex lytic cycle of T. gondii in situ by genera ...[more]
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