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Practical Strategy to 1,1'-Dideoxygossypol Derivatives from Gossypol and Its Antitumor Activities.

ABSTRACT: A practical and scalable route for the synthesis of 1,1'-dideoxygossypol from natural polyphenol product gossypol is described. The key step is the successful regioselective deacetylation of hexaacetyl apogossypol 9 and the following reductive removal of hydroxyl groups. The two steps of deacetylation occurred on the different sites under different conditions. The synthetic route follows a simple protection-deprotection strategy, and the yields of each step are over 85%. The total yield of this 9-step synthesis is over 40%, which is much better than the reported total synthesis method. The antitumor results illustrate that 1,1'-hydroxyl groups are not necessary for antitumor activities. In addition, 1,1'-dideoxygossypol has superior aqueous solubility (215 mg/L) compared to gossypol (64 mg/L).

SUBMITTER: Wang W

PROVIDER: S-EPMC9260933 | biostudies-literature |

REPOSITORIES: biostudies-literature

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