Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC9263050 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Angiogenesis is a process that results in the formation of new blood vessels. Similar to normal tissues, solid tumours require new blood vessels for growth and survival. Hence, drugs targeting angiogenesis may be useful treatment options for patients with bowel cancer.
AMG386 and bevacizumab act on 2 different pathways relevant to angiogenesis. There is evidence from laboratory and animal studies to suggest that such a combination could be useful as a cancer treatment. Previous studies in humans have shown that AMG386 and bevacizumab can be combined safely.. This study aims to evaluate the effectiveness and safety of the combination of AMG386 and bevacizumab in patients with advanced bowel cancer.
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