Assessment of the possible ameliorative effect of curcumin nanoformulation on the submandibular salivary gland of alloxan-induced diabetes in a rat model (Light microscopic and ultrastructural study).

ABSTRACT:

Background

Nowadays, attention is directed to herbal treatments in an attempt to lessen the adverse effects of diabetes. Nanoformulation of curcumin (NC) was shown to enhance stability and water solubility compared to native curcumin.

Objective

To examine the effect of different NC concentrations on the histopathological structure of the submandibular salivary gland of diabetic rats.

Methods

28 rats were divided equally into 4 groups. Group I: Control group, Group II (diabetic), III (diabetic + nanocurcumin low dose), and IV (diabetic + nanocurcumin high dose): Rats of groups II, III and IV were injected with a single dose of alloxan (140 mg/kg) to induce diabetes. After 7 days, groups III and IV were treated for 6 weeks with NC (100 mg/kg/

SUBMITTER: El Shahawy M 

PROVIDER: S-EPMC9263756 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature