Ontology highlight
ABSTRACT:
SUBMITTER: Martinez VS
PROVIDER: S-EPMC9269948 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Martínez Verónica S VS Saa Pedro A PA Jooste Jason J Tiwari Kanupriya K Quek Lake-Ee LE Nielsen Lars K LK
PLoS computational biology 20220627 6
The topology of metabolic networks is recognisably modular with modules weakly connected apart from sharing a pool of currency metabolites. Here, we defined modules as sets of reversible reactions isolated from the rest of metabolism by irreversible reactions except for the exchange of currency metabolites. Our approach identifies topologically independent modules under specific conditions associated with different metabolic functions. As case studies, the E.coli iJO1366 and Human Recon 2.2 geno ...[more]