Dataset Information

Progression to Critical Illness and Death in Patients With Breakthrough Hospitalizations.

ABSTRACT:

Background

Characterization of disease progression and outcomes after coronavirus disease 2019 (COVID-19)-related hospitalization in vaccinated compared with unvaccinated individuals is limited.

Methods

This was a retrospective case-control study of symptomatic vaccinated (cases) and unvaccinated (controls) participants hospitalized for COVID-19 between December 30, 2020, and September 30, 2021, in Southeast Michigan. Hospitalized adult patients with lab-confirmed COVID-19 were identified through daily census report. Breakthrough infection was defined as detection of severe acute respiratory syndrome coronavirus 2 ≥14 days after completion of the primary vaccination series. The association between prior vaccination and critical COVID-19 illness (composite of intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], 28-day mortality) was examined.

Results

Two hundred ten (39%) fully vaccinated and 325 (61%) unvaccinated patients were evaluated. Compared with controls, cases were older, had more comorbidities (4 [3-7] vs 2 [1-4]; P < .001), and were more likely to be immunocompromised. Cases had less severe symptoms compared with controls (2 [1-2] vs 2 [2-3]; P < .001) and were less likely to progress to critical COVID-19 illness (33.3% vs 45.5%; P < .001); 28-day mortality was significantly lower in cases (11.0% vs 24.9%; P < .001). Symptom severity (odds ratio [OR], 2.59; 95% CI, 1.61-4.16; P < .001) and modified Sequential Organ Failure Assessment score on presentation (OR, 1.74; 95% CI, 1.48-2.06; P < .001) were independently associated with development of critical COVID-19 illness. Prior vaccination (OR, 0.528; 95% CI, 0.307-0.910; P = .020) was protective.

Conclusions

COVID-19-vaccinated patients were less likely to develop critical COVID-19 illness and more likely to survive. Disease severity at presentation was a predictor of adverse outcomes regardless of vaccination status.

SUBMITTER: Suleyman G

PROVIDER: S-EPMC9272434 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Progression to Critical Illness and Death in Patients With Breakthrough Hospitalizations.

Suleyman Geehan G Fadel Raef R Alsaadi Ayman A Sueng Luis Ng LN Ghandour Ali A Alkhatib Ahmad A Singh Tarandeep T Parsons Austin A Miller Joseph J Ramesh Mayur M Brar Indira I Alangaden George G

Open forum infectious diseases 20220421 7

<h4>Background</h4>Characterization of disease progression and outcomes after coronavirus disease 2019 (COVID-19)-related hospitalization in vaccinated compared with unvaccinated individuals is limited.<h4>Methods</h4>This was a retrospective case-control study of symptomatic vaccinated (cases) and unvaccinated (controls) participants hospitalized for COVID-19 between December 30, 2020, and September 30, 2021, in Southeast Michigan. Hospitalized adult patients with lab-confirmed COVID-19 were id ...[more]

PMID: 35821729

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Dataset Information

Progression to Critical Illness and Death in Patients With Breakthrough Hospitalizations.

Background

Methods

Results

Conclusions

Publications

Progression to Critical Illness and Death in Patients With Breakthrough Hospitalizations.

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