Dataset Information

UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D₂ without improving overall vitamin D status: a randomized controlled trial.

ABSTRACT:

Purpose

This study investigated whether UVB-exposed wheat germ oil (WGO) is capable to improving the vitamin D status in healthy volunteers.

Methods

A randomized controlled human-intervention trial in parallel design was conducted in Jena (Germany) between February and April. Ultimately, 46 healthy males and females with low mean 25-hydroxyvitamin D (25(OH)D) levels (34.9 ± 10.6 nmol/L) were randomized into three groups receiving either no WGO oil (control, n = 14), 10 g non-exposed WGO per day (- UVB WGO, n = 16) or 10 g WGO, which was exposed for 10 min to ultraviolet B-light (UVB, intensity 500-630 µW/cm²) and provided 23.7 µg vitamin D (22.9 µg vitamin D₂ and 0.89 µg vitamin D₃) (+ UVB WGO, n = 16) for 6 weeks. Blood was obtained at baseline, after 3 and 6 weeks and analyzed for serum vitamin D-metabolite concentrations via LC-MS/MS.

Results

Participants who received the UVB-exposed WGO were characterized by an increase of circulating 25(OH)D₂ after 3 and 6 weeks of intervention. However, the 25(OH)D₃ concentrations decreased in the + UVB WGO group, while they increased in the control groups. Finally, the total 25(OH)D concentration (25(OH)D₂ + 25(OH)D₃) in the + UVB WGO group was lower than that of the non-WGO receiving control group after 6 weeks of treatment. In contrast, circulating vitamin D (vitamin D₂ + vitamin D₃) was higher in the + UVB WGO group than in the control group receiving no WGO.

Conclusion

UVB-exposed WGO containing 23.7 µg vitamin D can increase 25(OH)D₂ levels but do no improve total serum levels of 25(OH)D of vitamin D-insufficient subjects.

Trial registration

ClinicalTrials.gov: NCT03499327 (registered, April 13, 2018).

SUBMITTER: Bailer AC

PROVIDER: S-EPMC9279215 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The physiological relevance C-3 epimer of 25-hydroxyvitamin D (3-epi-25(OH)D) is not well understood among youth. The objective of this study was to assess whether demographic/physiologic characteristics were associated with 3-epi-25(OH)D3 concentrations in youth. Associations between 3-epi-25(OH)D3 and demographics and between 3-epi-25(OH)D3, total 25-hydroxyvitamin (25(OH)D) (25(OH)D2 + 25(OH)D3), total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were examined in racially/ethnically diverse schoolchildren (n = 682; age, 8-15 years) at Boston-area urban schools. Approximately 50% of participants had detectable 3-epi-25(OH)D3 (range 0.95-3.95 ng/mL). The percentage of 3-epi-25(OH)D3 of total 25(OH)D ranged from 2.5% to 17.0% (median 5.5%). Males were 38% more likely than females to have detectable 3-epi-25(OH)D3 concentrations. Both Asian and black race/ethnicity were associated with lower odds of having detectable 3-epi-25(OH)D3 compared with non-Hispanic white children (Asian vs. white, odds ratio (OR) 0.28, 95% confidence interval (CI) 0.14-0.53; black vs. white, OR 0.38, 95%CI 0.23-0.63, p < 0.001). Having an adequate (20-29 ng/mL) or optimal (>30 ng/mL) 25(OH)D concentration was associated with higher odds of having detectable 3-epi-25(OH)D3 than having an inadequate (<20 ng/mL) concentration (OR 4.78, 95%CI 3.23-6.94 or OR 14.10, 95%CI 7.10-28.0, respectively). There was no association between 3-epi-25(OH)D3 and blood lipids. However, when considering 3-epi-25(OH)D3 as a percentage of total 25(OH)D, total cholesterol was lower in children with percent 3-epi-25(OH)D3 above the median (mean difference -7.1 mg/dL, p = 0.01). In conclusion, among schoolchildren, sex, race/ethnicity, and total serum 25(OH)D concentration is differentially associated with 3-epi-25(OH)D. The physiological relevance of 3-epi-25(OH)D3 may be related to the 3-epi-25(OH)D3 as a percentage of total 25(OH)D and should be considered in future investigations.

Dataset Information

UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D₂ without improving overall vitamin D status: a randomized controlled trial.

Purpose

Methods

Results

Conclusion

Trial registration

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Dataset Information

UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D2 without improving overall vitamin D status: a randomized controlled trial.

Purpose

Methods

Results

Conclusion

Trial registration

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OmicsDI is part of the ELIXIR infrastructure

Tweets

UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D₂ without improving overall vitamin D status: a randomized controlled trial.