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A Ring Expansion Approach To N-oxy-2,5-diketopiperazines.

ABSTRACT: A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to N-oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing N-oxy-2,5-DKP natural products.

SUBMITTER: Jackson AC

PROVIDER: S-EPMC9281442 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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A Ring Expansion Approach To N-oxy-2,5-diketopiperazines.

Jackson Amy C AC Olsen James T JT Sundstrom Sasha S Lambert Kyle M KM Wood John L JL

Tetrahedron letters 20220518

A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to N-oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing N-oxy-2,5-DKP natural products. ...[more]

PMID: 35846850

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