MCRP as a Biomarker of Adult-Onset Still's Disease: Quantification of mCRP by ELISA.

ABSTRACT:

Background

C-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms. mCRP exhibits strong pro-inflammatory activity and activates platelets, leukocytes, and endothelial cells. Abundant deposition of mCRP in inflamed tissues plays a role in several disease conditions, such as ischemia/reperfusion injury, Alzheimer's disease, and cardiovascular disease. Although pCRP is typically quantified rather than mCRP for clinical purposes, mCRP may be a more appropriate disease marker of inflammatory diseases. Therefore, simple methods for quantifying mCRP are needed.

Methods

We developed a specific enzyme-linked immunosorbent ass

SUBMITTER: Fujita C 

PROVIDER: S-EPMC9284222 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature