Transcriptomics

Dataset Information

0

Monocyte gene expression in adult-onset Still's disease


ABSTRACT: Adult-onset Still’s disease (AOSD) is a rare autoinflammatory disease, characterized by fever, rash, arthritis and other systemic inflammatory manifestations like hepatosplenomegaly and serositis. One of the most serious complications AOSD is macrophage activation syndrome (MAS), a life-threatening condition caused by excessive activation of immune system and a cytokine storm. Clinical features of MAS include continuous high fever, hepatosplenomegaly, liver dysfunction, lymphadenopathy, hyperferritinemia, and hemophagocytosis. The prevalence of MAS in AOSD patients is estimated to be between 10–19%, but the mortality rate of AOSD-associated MAS is approximately 10–20%. The precise mechanism by which AOSD develops to MAS remains unclear. There is an unmet need to investigate the pathogenesis of MAS in AOSD in order to identify novel biomarkers and therapeutic targets to improve disease prognosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247993 | GEO | 2023/12/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-05-22 | GSE150996 | GEO
2018-02-12 | GSE103170 | GEO
2014-09-08 | GSE57253 | GEO
2011-06-20 | E-GEOD-17732 | biostudies-arrayexpress
2016-04-29 | E-GEOD-80060 | biostudies-arrayexpress
2016-04-29 | GSE80060 | GEO
2014-09-08 | E-GEOD-57253 | biostudies-arrayexpress
2015-08-01 | E-GEOD-70019 | biostudies-arrayexpress
2011-06-20 | GSE17732 | GEO
2010-01-10 | PXD016341 | Pride