Multicomponent Copolymer Planar Membranes with Nanoscale Domain Separation.

ABSTRACT: Domain separation is crucial for proper cellular function and numerous biomedical technologies, especially artificial cells. While phase separation in hybrid membranes containing lipids and copolymers is well-known, the membranes' overall stability, limited by the lipid part, is hindering the technological applications. Here, we introduce a fully synthetic planar membrane undergoing phase separation into domains embedded within a continuous phase. The mono- and bilayer membranes are composed of two amphiphilic diblock copolymers (PEO₄₅-b-PEHOx₂₀ and PMOXA₁₀-b-PDMS₂₅) with distinct properties and mixed at various concentrations. The molar ratio of the copolymers in the mixture and the nature of the solid support were the key parameters inducing nanoscale phase separation of the planar membranes. The size of the domains and resulting morphology of the nanopatterned surfaces were tailored by adjusting the molar ratios of the copolymers and transfer conditions. Our approach opens new avenues for the development of biomimetic planar membranes with a nanoscale texture.

SUBMITTER: Bina M 

PROVIDER: S-EPMC9284607 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature