Unknown

Dataset Information

0

Prevalence and incidence of diabetic retinopathy (DR) in the UK population of Gloucestershire.


ABSTRACT:

Purpose

To estimate prevalence and incidence of diabetic retinopathy (DR) in a UK region by severity between 2012 and 2016 and risk factors for progression to proliferative DR (PDR).

Methods

Electronic medical records from people with diabetes (PWD) ≥18 years seen at the Gloucestershire Diabetic Eye Screening Programme (GDESP) and the hospital eye clinic were analysed (HEC). Prevalence and incidence of DR per 100 PWD (%) by calendar year, grade and diabetes type were estimated using log-linear regression. Progression to PDR and associated risk factors were estimated using parametric survival analyses.

Results

Across the study period, 35 873 PWD had at least one DR assessment. They were aged 66 (56-75) years (median (interquartile range)), 57% male, 5 (1-10) years since diabetes diagnosis, 93% Type 2 diabetes. Prevalence of DR decreased from 38.9% (95% CI: 38.1%, 39.8%) in 2012 to 36.6% (95% CI: 35.9%, 37.3%) in 2016 (p < 0.001). Incidence of any DR decreased from 10.9% (95% CI: 10.4%, 11.5%) in 2013 to 8.5% (95% CI: 8.1%, 9.0%) in 2016 (p < 0.001). Prevalence of PDR decreased from 3.5% (95% CI: 3.3%, 3.8%) in 2012 to 3.1% (95% CI 2.9%, 3.3%) in 2016 (p = 0.008). Incidence of PDR did not change over time. HbA1c and bilateral moderate-severe NPDR were statistically significant risk factors associated with progression to PDR.

Conclusions

Incidence and prevalence of DR decreased between 2012 and 2016 in this well-characterized population of the UK.

SUBMITTER: Scanlon PH 

PROVIDER: S-EPMC9290830 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9353559 | biostudies-literature
| S-EPMC6138139 | biostudies-other
| S-EPMC8212402 | biostudies-literature
| S-EPMC4712887 | biostudies-literature
| S-EPMC3384630 | biostudies-other
| S-EPMC10716530 | biostudies-literature
| S-EPMC5776499 | biostudies-literature
| S-EPMC5341621 | biostudies-literature
| S-EPMC7371214 | biostudies-literature
| S-EPMC10413718 | biostudies-literature