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Synthesis of Silylated Cyclobutanone and Cyclobutene Derivatives Involving 1,4-Addition of Zinc-Based Silicon Nucleophiles.

ABSTRACT: A copper-catalyzed conjugate silylation of various cyclobutenone derivatives with Me₂ PhSiZnCl ⋅ 2LiCl or (Me₂ PhSi)₂ Zn ⋅ xLiCl (x≤4) to generate β-silylated cyclobutanones is reported. Trapping the intermediate enolate with ClP(O)(OPh)₂ affords silylated enol phosphates that can be further engaged in Kumada cross-coupling reactions to yield silylated cyclobutene derivatives.

SUBMITTER: Cui M

PROVIDER: S-EPMC9292915 | biostudies-literature |

REPOSITORIES: biostudies-literature

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