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Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow cells originating from immature myeloid cells. They exert potent immunosuppressive activity and are closely associated with the development of various diseases such as malignancies, infections, and inflammation. In malignant tumors, MDSCs, one of the most dominant cellular components comprising the tumor microenvironment, play a crucial role in tumor growth, drug resistance, recurrence, and immune escape. Although the role of MDSCs in solid tumors is currently being extensively studied, little is known about their role in hematologic malignancies. In this review, we comprehensively summarized and reviewed the different roles of MDSCs in hematologic malignancies and hematopoietic stem cell transplantation, and finally discussed current targeted therapeutic strategies.Affiliation: Kindly check and confirm the processed affiliations are correct. Amend if any.correct.

SUBMITTER: Yu S

PROVIDER: S-EPMC9295421 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin.

Yu Shunjie S Ren Xiaotong X Li Lijuan L

Experimental hematology & oncology 20220719 1

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow cells originating from immature myeloid cells. They exert potent immunosuppressive activity and are closely associated with the development of various diseases such as malignancies, infections, and inflammation. In malignant tumors, MDSCs, one of the most dominant cellular components comprising the tumor microenvironment, play a crucial role in tumor growth, drug resistance, recurrence, and immune escape. Alth ...[more]

PMID: 35854339

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