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Tumor vessel normalization and immunotherapy in gastric cancer.


ABSTRACT: Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization has been shown to improve the efficacy of cancer immunotherapy, which in turn may be improved through enhanced immune stimulation. Therefore, it may be interesting to identify synergies between immunomodulatory agents and anti-angiogenic therapies in GC. This strategy aims to normalize the tumor microenvironment through the action of the anti-vascular endothelial growth factor while stimulating the immune response through immunotherapy and prolonging the survival of GC patients.

SUBMITTER: Yu X 

PROVIDER: S-EPMC9297465 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Tumor vessel normalization and immunotherapy in gastric cancer.

Yu Xianzhe X   He Shan S   Shen Jian J   Huang Qiushi Q   Yang Peng P   Huang Lin L   Pu Dan D   Wang Li L   Li Lu L   Liu Jinghua J   Liu Zelong Z   Zhu Lingling L  

Therapeutic advances in medical oncology 20220718


Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization has been shown to improve the efficacy of cancer immunotherapy, which in turn may be improved through enhanced immune stimulation. Therefore, it may be interesting to identify synergies between immuno  ...[more]

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