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ABSTRACT: Objective
The disordered growth of nerve stumps after amputation leading to the formation of neuromas is an important cause of postoperative pain in amputees. This severely affects the patients' quality of life. Regenerative peripheral nerve interfaces (RPNIs) are an emerging method for neuroma prevention, but its postoperative nerve growth and pathological changes are yet to be studied.Methods
The rat sciatic nerve transection model was used to study the effectiveness of RPNI in this experiment. The RPNI (experimental) group (n = 11) underwent RPNI implantation after sciatic nerve transection, while the control group (n = 11) only underwent sciatic nerve transection. Autotomy behavior, ultrasonography, and histopathology were observed for 2 months postoperatively.Results
Compared to the control group, the incidence and size of the neuromas formed and the incidence and extent of autotomy were significantly reduced in the RPNI group. The axon density in the stump and degree of stump fibrosis were also significantly reduced in the RPNI group.Conclusion
RPNI effectively prevented the formation of neuromas.
SUBMITTER: Wu J
PROVIDER: S-EPMC9301297 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Wu Jiaqing J Zhang Yajun Y Zhang Xiaoyuan X Lin Zhiyu Z Li Guangxue G
Frontiers in molecular neuroscience 20220707
<h4>Objective</h4>The disordered growth of nerve stumps after amputation leading to the formation of neuromas is an important cause of postoperative pain in amputees. This severely affects the patients' quality of life. Regenerative peripheral nerve interfaces (RPNIs) are an emerging method for neuroma prevention, but its postoperative nerve growth and pathological changes are yet to be studied.<h4>Methods</h4>The rat sciatic nerve transection model was used to study the effectiveness of RPNI in ...[more]