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Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426.

ABSTRACT: Two new indole diketopiperazines (1-2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3-11). The structures of 1-2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5-7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC₅₀ value of 4.6 μM.

SUBMITTER: Lv D

PROVIDER: S-EPMC9301495 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426.

Lv Dongli D Xia Jinmei J Guan Xiaoqing X Lai Qiliang Q Zhang Beibei B Lin Jianhui J Shao Zongze Z Luo Sulan S Zhangsun Dongting D Qin Jiang-Jiang JJ Wang Weiyi W

Frontiers in microbiology 20220707

Two new indole diketopiperazines (1-2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3-11). The structures of 1-2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5-7 significantly inhibited the growth of Staphylococcus aureus. Meanwhil ...[more]

PMID: 35875553

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