Thiazole-Formulated Azomethine Compound for Three-Way Detection of Mercury Ions in Aqueous Media and Application in Living Cells
Ontology highlight
ABSTRACT:
SUBMITTER: Umabharathi P
PROVIDER: S-EPMC9301703 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:Hg and Cd are the two most toxic heavy metal ions that could be found in aqueous solutions. In this study, a chemosensor based on 5-(4-((4-nitrophenyl) diazenyl) phenyl)-1,3,4-oxadiazole-2-thiol (DOT) was reported to detect these ions simultaneously. DOT showed high selectivity towards Hg ion by changing the color of the solution from beige to gold-yellow at different concentrations of Hg ion. In comparison, other relevant metals, such as Li+, Na+, K+, Cs+, Mg2+, Ca2+, Al3+, Fe2+, Ag+, Cu2+, Pb2+, Ni2+, Zn2+, Cr3+, Fe3+, Pb4+, Mn2+, and Cd2+ did not affect the color of the DOT solution as the interfering ions. Despite no changes in the color of DOT solution in the presence of Cd ion, a solution containing DOT-Hg complex was changed from gold-yellow to orange by adding Cd ion, providing an approach for detecting Hg and Cd ion simultaneously with UV-Vis and Fluorescent spectroscopy. DOT exhibited a high association constant with a detection limit of 0.05 μM for Hg and Cd ions in an aqueous solution. The results of quantum mechanics (QM) calculations were also consistent with the experimental observations, which indicated that changes in the band gap could explain the various colors of DOT complex with metal ions.
| S-EPMC10682545 | biostudies-literature
Project description:Uranium is one of the most common radioactive contaminants in the environment. As a major nuclear material in production, environmental samples (like soil and groundwater) can provide signatures on uranium production activity inside the facility. Thus, developing a new and portable analytical technology for uranium in aqueous media is significant not only for environmental monitoring, but also for nonproliferation. In this work, a label-free method for the detection of uranyl (UO22+) ions is developed by monitoring the translocation of a peptide probe in a nanopore. Based on the difference in the number of peptide events in the absence and presence of uranyl ions, nanomolar concentration of UO22+ ions could be detected in minutes. The method is highly selective; micromolar concentrations of Cd2+, Cu2+, Zn2+, Ni2+, Pb2+, Hg2+, Th4+, Mg2+, and Ca2+ would not interfere with the detection of UO22+ ions. In addition, simulated water samples were successfully analyzed.
| S-EPMC5450019 | biostudies-literature
Project description:Pollution from heavy metal ions has become a major issue worldwide. Water pollution, particularly with heavy metals like mercury, is a global problem. Developing environmentally friendly, low-cost, high-efficiency, sensitive, and selective sensors for the detection of mercury(ii) ions in aqueous environments has attracted great interest in industry and academia. In this research paper, a bodipy-functionalized magnetic fluorescent MSp-TAB hybrid material was developed for detecting mercury(ii) in aqueous media. The magnetic fluorescent MSp-TAB hybrid material was characterized using FT-IR, SEM, EDX, XRD, and TGA. We studied the influence of diverse factors such as contact time, temperature, and pH on the detection of Hg(ii). The fluorometric study demonstrated that the developed magnetic-fluorescent hybrid material was sensitive/selective for Hg(ii) ions in the absence and presence of interfering ions with a limit of detection (LOD) of 2.72 μM. In conclusion, the developed magnetic fluorescent MSp-TAB hybrid material has demonstrated its applicability and potential for accurate, sensitive, and practical detection of Hg(ii) in tap water samples.
| S-EPMC11472347 | biostudies-literature
Project description:In photoactivation strategies with bioactive molecules, one-photon visible or two-photon near-infrared light-sensitive caged compounds are desirable tools for biological applications because they offer reduced phototoxicity and deep tissue penetration. However, visible-light-sensitive photoremovable protecting groups (PPGs) reported so far have displayed high hydrophobicity and low uncaging cross sections (εΦ < 50) in aqueous media, which can obstruct the control of bioactivity with high spatial and temporal precision. In this study, we developed hydroxylated thiazole orange (HTO) derivatives as visible-light-sensitive PPGs with high uncaging cross sections (εΦ ≈ 370) in aqueous solution. In addition, 2PE photolysis reactions of HTO-caged glutamate were achieved using a NIR laser (940 nm). Moreover, HTO-caged glutamate can activate N-methyl-d-aspartic acid receptors in Xenopus oocytes and mammalian cells with green-light illumination, thus allowing optical control of biological functions.
| S-EPMC9241960 | biostudies-literature
Project description:Using a green biosorbent to remove toxic mercury ions from aqueous solutions is a significant undertaking. In the present study, a novel biosorbent, l-cysteine modified cellulose nanocrystals (Lcys-CNCs), was prepared by functionalizing high surface area cellulose nanocrystals with l-cysteine through periodate oxidation and reductive amination reaction. Lcys-CNCs were characterized by FT-IR, 13C CP-MAS NMR, elemental analysis, XPS, zeta potential and SEM. As cellulose nanocrystals are the natural nanomaterial, and l-cysteine contains strong mercury chelating groups, Lcys-CNCs show excellent adsorption capacity for mercury ions. The experimental conditions such as pH, contact time, and initial mercury ion concentration are discussed. The pseudo-second order model can describe the removal kinetics of Hg(ii) more accurately than the pseudo-first order model. The adsorption isotherm study of Hg(ii) followed the Langmuir model of monolayer adsorption. The maximum uptake capacity of Lcys-CNCs was determined to be 923 mg g-1. Lcys-CNCs can remove mercury ions with 93% removal efficiency within 5 min from a 71 mg L-1 solution. For Cd(ii), Pb(ii), Cu(ii) and Zn(ii) ions, Lcsy-CNCs can selectively adsorb Hg(ii) ions and the removal efficiency is 87.4% for Hg(ii). This study suggests Lcsy-CNCs are a green and highly efficient biosorbent for adsorption of mercury ions from aqueous solutions.
| S-EPMC9061121 | biostudies-literature
Project description:The selective and efficient monitoring of mercury (Hg2+ ) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8-naphthalimide-based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg2+ with high selectivity and sensitivity and a low detection limit of 13 nm. The detection mechanism was based on a Hg2+ -triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg2+ in living cells and zebrafish with low cytotoxicity.
| S-EPMC8562314 | biostudies-literature
Project description:The goal of this project is to explore a new method to efficiently remove Pb(II) ions from water by processing Undaria pinnatifida into immobilized beads using sodium alginate and calcium chloride. The resulting biosorbent was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS). Using immobilized U. pinnatifida, we investigated the effect of various factors on Pb(II) ion removal efficiency such as temperature, pH, ionic strength, time, and underlying biosorption mechanisms. For Pb(II) ion biosorption studies, Pb(II) ion biosorption data were obtained and analyzed using Langmuir and Freundlich adsorption models. It is found that the maximum Pb(II) ion adsorption capacity (X m) of U. pinnatifida was estimated to be ∼5 times greater than that of activated carbon, indicating the superior Pb(II) ion removal capability of U. pinnatifida compared to activated carbon. In addition, a thermodynamic study indicates that biosorption processes are found to be endothermic and an increase in the Pb(II) ion solution temperature provides a more preferential reaction toward Pb(II) ion biosorption.
| S-EPMC9648066 | biostudies-literature
Project description:We designed a recyclable Hg(2+) probe based on Rhodamine B isothiocyanate (RBITC)-poly(ethylene glycol) (PEG)-comodified gold nanoparticles (AuNPs) with excellent robustness, selectivity, and sensitivity. On the basis of a rational design, only Hg(2+) can displace RBITC from the AuNP surfaces, resulting in a remarkable enhancement of RBITC fluorescence initially quenched by AuNPs. To maintain stability and monodispersity of AuNPs in real samples, thiol-terminated PEG was employed to bind with the remaining active sites of AuNPs. Besides, this displacement assay can be regenerated by resupplying free RBITC into the AuNPs solutions that were already used for detecting Hg(2+). Importantly, the detection limit of this assay for Hg(2+) (2.3 nM) was lower than the maximum limits guided by the United States Environmental Protection Agency as well as that permitted by the World Health Organization. The efficiency of this probe was demonstrated in monitoring Hg(2+) in complex samples such as river water and living cells.
| S-EPMC3528810 | biostudies-literature
Project description:Boosting the transport and selectivity properties of membranes based on polymers of intrinsic microporosity (PIMs) toward one specific working analyte of interest is challenging. In this work, a novel family of PIM membranes, prepared by casting and exhibiting optima mechanical properties and high thermal stability, was synthesized from 4,4'-(2,2,2-trifluoro-1-phenylethane-1,1-diyl) bis(benzene-1,2-diol) and two tetrafluoro-nitrile derivatives. Gas permeability measurements evidenced a CO2/CH4 selectivity up to 170% relative to the reference polymer, PIM-1, in agreement with their calculated fractional free volume and the analysis of the textural properties by N2 and CO2 gas adsorption. Besides, the chemical modification by acid hydrolysis of the PIM membranes favored the permeability for lithium ions (LiCl 2M, 6 × 10-9 cm2·s-1) compared to other alkali metal analogs such as sodium (NaCl 2M, 7.38 × 10-10 cm2·s-1) and potassium (KCl 2M, 1.05 × 10-9 cm2·s-1). Moreover, the complete mitigation of the crossover of redox species with higher molecular sizes than the ions from alkali metal salts was confirmed by using in-line benchtop NMR methods. Additionally, the modified PIM membranes were measured in a symmetric electrochemical flow cell using an aqueous electrolyte by combining lithium ferro/ferricyanide redox compounds and lithium chloride. The electrochemical tests showed low polarization, high-rate capability, and capacity retention values of 99% when cycled at 10 mA·cm-2 for over 50 cycles. Based on these results, these polymers could be used as highly selective and conducting membranes in electrodialysis for lithium separation and lithium-based redox flow batteries and as a protective layer in high-energy density lithium metal batteries.
| S-EPMC11468783 | biostudies-literature
Project description:A simple Schiff-base ligand 2-hydroxy-1-naphthaldehyde semicarbazone (HNS) was synthesized and characterized. Based on the combined effect of inhibition of CH[double bond, length as m-dash]N isomerization and chelation-enhanced fluorescence (CHEF), HNS functions as a fluorescence "turn on" sensor for Al3+ in buffered aqueous media. Based on the strong affinity of Al3+ to F- ions, the in situ generated Al3+-HNS complex can also be utilized as an effective chemosensor for F- sensing by metal displacement approach, ensuing quenching of fluorescence by the reversible return of HNS from Al3+-HNS complex. Thus a method using a single probe for the detection of both Al3+ and F- ions is developed. The system exhibits high selectivity and sensitivity for Al3+ and F- ions and the detection limits were found to be as low as 6.75 × 10-8 M and 7.89 × 10-7 M, respectively. Furthermore, the practical applicability of this probe has been examined in living cells.
| S-EPMC9054392 | biostudies-literature