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A Naphthalimide-Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells.

ABSTRACT: The selective and efficient monitoring of mercury (Hg²⁺ ) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8-naphthalimide-based fluorescent probe NADP for the detection of Hg²⁺ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg²⁺ with high selectivity and sensitivity and a low detection limit of 13 nm. The detection mechanism was based on a Hg²⁺ -triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg²⁺ in living cells and zebrafish with low cytotoxicity.

SUBMITTER: Lei S

PROVIDER: S-EPMC8562314 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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A Naphthalimide-Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells.

Lei Shaoyu S Meng Xia X Wang Lizhen L Zhou Jianhua J Qin Dawei D Duan Hongdong H

ChemistryOpen 20211101 11

The selective and efficient monitoring of mercury (Hg2+ ) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8-naphthalimide-based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg2+ with high selectivity and sensitivity and a low detection limit of 13 nm. The detection mechanism was based on a Hg2+ -triggere ...[more]

PMID: 34726842

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