Unknown

Dataset Information

0

Rhodium-Catalyzed C-H Methylation and Alkylation Reactions by Carbene-Transfer Reactions.


ABSTRACT: In this combined computational and experimental study, the C-H functionalization of 2-phenyl pyridine with diazoalkanes was investigated. Initial evaluation by computational methods allowed the evaluation of different metal catalysts and diazoalkanes and their compatibility in this C-H functionalization reaction. With these findings, suitable reaction conditions for the C-H methylation reactions were quickly identified by using highly reactive TMS diazomethane and C-H alkylation reactions with donor/acceptor diazoalkanes, which is applied to a broad scope on alkylation reactions of 2-aryl pyridines with TMS diazomethane and donor/acceptor diazoalkane (51 examples, up to 98 % yield).

SUBMITTER: Empel C 

PROVIDER: S-EPMC9302633 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7898811 | biostudies-literature
| S-EPMC4742333 | biostudies-other
| S-EPMC4531321 | biostudies-other
| S-EPMC4965293 | biostudies-literature
| S-EPMC8179253 | biostudies-literature
| S-EPMC3905989 | biostudies-literature
| S-EPMC5207348 | biostudies-literature
| S-EPMC5585739 | biostudies-literature
| S-EPMC3312017 | biostudies-literature
| S-EPMC2836487 | biostudies-literature