Ontology highlight
ABSTRACT:
SUBMITTER: Khan TG
PROVIDER: S-EPMC9305350 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Khan Taslima Gani TG Ginsburg David D Emmer Brian T BT
Journal of lipid research 20220624 8
The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density lipoproteins (LDLs), a process that modulates the development of atherosclerotic cardiovascular disease. We recently identified RAB10, encoding a small GTPase, as a positive regulator of LDL uptake in hepatocellular carcinoma cells (HuH7) in a genome-wide CRISPR screen, though the underlying molecular mechanism for this effect was unknown. We now report that RAB10 regulates hepatocyte LDL uptake by ...[more]