Circulating levels of urocortin neuropeptides are impaired in children with overweight.

ABSTRACT:

Objective

The corticotropin-releasing factor neuropeptides (corticotropin-releasing hormone [CRH] and urocortin [UCN]-1,2,3) and spexin contribute to the regulation of energy balance and inhibit food intake in mammals. However, the status of these neuropeptides in children with overweight has yet to be elucidated. This study investigated the effect of increased body weight on the circulating levels of these neuropeptides.

Methods

A total of 120 children with a mean age of 12 years were enrolled in the study. Blood samples were collected to assess the circulating levels of neuropeptides and were correlated with various anthropometric, clinical, and metabolic markers.

Results

Plasma levels of UCNs were altered in children with overweight but less so in those with obesit

SUBMITTER: Kavalakatt S 

PROVIDER: S-EPMC9305428 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature