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Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents.

ABSTRACT: Boronic acids are Lewis acids that exist in equilibrium with boronate forms in aqueous solution. Here we experimentally and computationally investigated the Lewis acidity of 2,6-diarylphenylboronic acids; specially designed phenylboronic acids that possess two flanking aromatic rings with tunable aromatic character. Hammett analysis of 2,6-diarylphenylboronic acids reveals that their Lewis acidity remains unchanged upon the introduction of EWG/EDG at the distant para position of the flanking aromatic rings. Structural and computational studies demonstrate that polar-π interactions and solvation effects contribute to the stabilization of boronic acids and boronate forms by aromatic rings. Our physical-organic chemistry work highlights that boronic acids and boronates can be stabilized by aromatic systems, leading to an important molecular knowledge for rational design and development of boronic acid-based catalysts and inhibitors of biomedically important proteins.

SUBMITTER: Jian J

PROVIDER: S-EPMC9306523 | biostudies-literature |

REPOSITORIES: biostudies-literature

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An Experimental Acidity Scale for Intramolecularly Stabilized Silyl Lewis Acids.

Project description:A new NMR-based Lewis acidity scale is suggested and its application is demonstrated for a family of silyl Lewis acids. The reaction of p-fluorobenzonitrile (FBN) with silyl cations that are internally stabilized by interaction with a remote chalcogenyl or halogen donor yields silylated nitrilium ions with the silicon atom in a trigonal bipyramidal coordination environment. The 19 F NMR chemical shifts and the 1 J(CF) coupling constants of these nitrilium ions vary in a predictable manner with the donor capability of the stabilizing group. The spectroscopic parameters are suitable probes for scaling the acidity of Lewis acids. These new probes allow for the discrimination between very similar Lewis acids, which is not possible with conventional NMR tests, such as the well-established Gutmann-Beckett method.

| S-EPMC6899571 | biostudies-literature

Soft interactions with hard Lewis acids: generation of mono- and dicationic alkaline-earth metal arene-complexes by direct oxidation.

Project description:The synthesis of the first unsupported dicationic arene complexes of calcium and strontium [(?6-HMB)AE(oDFB)4]2+ is reported (HMB = hexamethylbenzene; AE = alkaline earth metal; oDFB = ortho-difluorobenzene). They were prepared by direct oxidation of the elemental metals employing the ligand-forming radical cation salt [HMB][WCA] as an oxidant (WCA = [Al(ORF)4] or [?F-{Al(ORF)3}2]; RF = C(CF3)3). In addition, monocationic ?6-HMB complexes of calcium, strontium and barium supported by coordination of the monodentate anion [F-Al(ORF)3]- are reported. In all examples, almost undistorted ?6-HMB coordination is observed with rather short M-arenecentroid distances approaching those observed with the isoelectronic but negatively charged pentamethylcyclopentadienyl ligand. The structure and bonding, thermodynamic stability and Lewis acidity (fluoride/hydride ion affinities, FIA/HIA) of the generated complexes were assessed by DFT methods. It followed that the gaseous dications [(?6-HMB)AE(oDFB)4]2+ are extremely hard Lewis acids that retain FIAs close to superacidity in solution.

| S-EPMC7057851 | biostudies-literature

Probing the Impact of Solvent on the Strength of Lewis Acids via Fluorescent Lewis Adducts.

Project description:Various methods have been developed to measure the strength of a Lewis acid. A major challenge for these measurements lies in the complexity that arises from variable solvent interactions and perturbations of Lewis acids as their reaction environment changes. Herein, we investigate the impact of solvent effects on Lewis acids for the first time as measured by the fluorescent Lewis adduct (FLA) method. The binding of a Lewis acid in various solvents reveals a measurable dichotomy between both polarity and donor ability of the solvent. While not strictly separable, we observe that the influence of solvent polarity on Lewis acid unit (LAU) values is distinctly opposite to the influence of donor ability. This dichotomy was confirmed by titration data, illustrating that solvation effects can be appropriately and precisely gauged by the FLA method.

| S-EPMC10069026 | biostudies-literature

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters.

Project description:We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin-3-ol or 4-dimethylaminopyridine and a photoredox catalyst to generate carbon radicals from either boronic acids or esters. This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to react with electron-deficient olefins via radical addition to efficiently form C-C coupled products in a redox-neutral fashion. The Lewis base catalyst was shown to form a redox-active complex with either the boronic esters or the trimeric form of the boronic acids (boroxines) in solution.

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Multidimensional Lewis Acidity: A Consistent Data Set of Chloride, Hydride, Methide, Water and Ammonia Affinities for 183 p-Block Element Lewis Acids.

Project description:The computed fluoride ion affinity (FIA) is a widely applied descriptor to gauge Lewis acidity. Like every other single-parameter Lewis acidity scale, the FIA metric suffers from the one-dimensionality, that prohibits addressing Lewis acidity by the multidimensionality it inherently requires (i. e., reference Lewis base dependency). However, a systematic screening of computed affinities other than the FIA is much less developed. Herein, we extended our CCSD(T)/CBS benchmark of different density functionals and the DLPNO-CCSD(T) method for chloride (CIA), methide (MIA), hydride (HIA), water (WA), and ammonia (AA) affinities. The best performing methods are subsequently applied to yield nearly 800 affinities for 183 p-block element compounds of group 13-16 with an estimated accuracy of <10 kJ mol-1 . The study's output serves as a consistent library for qualitative analyses and a training set for future statistical approaches. A first holistic correlation analysis underscores the need for a multidimensional description of Lewis acidity.

| S-EPMC8252043 | biostudies-literature

Internal acidity scale and reactivity evaluation of chiral phosphoric acids with different 3,3'-substituents in Bronsted acid catalysis.

Project description:The concept of hydrogen bonding for enhancing substrate binding and controlling selectivity and reactivity is central in catalysis. However, the properties of these key hydrogen bonds and their catalyst-dependent variations are extremely difficult to determine directly by experiments. Here, for the first time the hydrogen bond properties of a whole series of BINOL-derived chiral phosphoric acid (CPA) catalysts in their substrate complexes with various imines were investigated to derive the influence of different 3,3'-substituents on the acidity and reactivity. NMR 1H and 15N chemical shifts and 1 J NH coupling constants of these hydrogen bonds were used to establish an internal acidity scale corroborated by calculations. Deviations from calculated external acidities reveal the importance of intermolecular interactions for this key feature of CPAs. For CPAs with similarly sized binding pockets, a correlation of reactivity and hydrogen bond strengths of the catalyst was found. A catalyst with a very small binding pocket showed significantly reduced reactivities. Therefore, NMR isomerization kinetics, population and chemical shift analyses of binary and ternary complexes as well as reaction kinetics were performed to address the steps of the transfer hydrogenation influencing the overall reaction rate. The results of CPAs with different 3,3'-substituents show a delicate balance between the isomerization and the ternary complex formation to be rate-determining. For CPAs with an identical acidic motif and similar sterics, reactivity and internal acidity correlated inversely. In cases where higher sterical demand within the binary complex hinders the binding of the second substrate, the correlation between acidity and reactivity breaks down.

| S-EPMC6977555 | biostudies-literature

Molecular Bismuth Cations: Assessment of Soft Lewis Acidity.

Project description:Three-coordinate cationic bismuth compounds [Bi(diaryl)(EPMe3 )][SbF6 ] have been isolated and fully characterized (diaryl=[(C6 H4 )2 C2 H2 ]2- , E=S, Se). They represent rare examples of molecular complexes with Bi⋅⋅⋅EPR3 interactions (R=monoanionic substituent). The 31 P NMR chemical shift of EPMe3 has been found to be sensitive to the formation of LA⋅⋅⋅EPMe3 Lewis acid/base interactions (LA=Lewis acid). This corresponds to a modification of the Gutmann-Beckett method and reveals information about the hardness/softness of the Lewis acid under investigation. A series of organobismuth compounds, bismuth halides, and cationic bismuth species have been investigated with this approach and compared to traditional group 13 and cationic group 14 Lewis acids. Especially cationic bismuth species have been shown to be potent soft Lewis acids that may prefer Lewis pair formation with a soft (S/Se-based) rather than a hard (O/N-based) donor. Analytical techniques applied in this work include (heteronuclear) NMR spectroscopy, single-crystal X-ray diffraction analysis, and DFT calculations.

| S-EPMC7818483 | biostudies-literature

Detection of boronic acids through excited-state intramolecular proton-transfer fluorescence.

Project description:Boronic acids are versatile reagents for the chemical synthesis of organic molecules. They and other boron-containing compounds can be detected readily by the interruption of the excited-state intramolecular proton transfer (ESIPT) of 10-hydroxybenzo[h]quinolone. This method is highly sensitive and selective, and useful for monitoring synthetic reactions and detecting boron-containing compounds on a solid support.

| S-EPMC3946559 | biostudies-literature

Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale.

Project description:A quantitative Lewis acidity/basicity scale toward boron-centered Lewis acids has been developed based on a set of 90 experimental equilibrium constants for the reactions of triarylboranes with various O-, N-, S-, and P-centered Lewis bases in dichloromethane at 20 °C. Analysis with the linear free energy relationship log KB =LAB +LBB allows equilibrium constants, KB , to be calculated for any type of borane/Lewis base combination through the sum of two descriptors, one for Lewis acidity (LAB ) and one for Lewis basicity (LBB ). The resulting Lewis acidity/basicity scale is independent of fixed reference acids/bases and valid for various types of trivalent boron-centered Lewis acids. It is demonstrated that the newly developed Lewis acidity/basicity scale is easily extendable through linear relationships with quantum-chemically calculated or common physical-organic descriptors and known thermodynamic data (ΔH BF3 ). Furthermore, this experimental platform can be utilized for the rational development of borane-catalyzed reactions.

| S-EPMC7985883 | biostudies-literature

Fluxionate Lewis acidity of the Zn2+ ion in carboxypeptidase A.

Project description:Competitive inhibition constants Ki for a series of phenol-ring-substituted derivatives of alpha-(2-hydroxyphenyl)benzenepropanoic acid have been ascertained by observing their influence on the catalytic hydrolysis of a peptide substrate by the zinc enzyme carboxypeptidase A. The pH-dependence of Ki shows that binding is maximal between two pKa values: one is that of the phenol group of the inhibitor, and the other uniformly has a value of 6, the pKa of a Zn(2+)-bound water molecule on the enzyme in the absence of substrate or inhibitor. This is the dependence expected if phenolate binds to the Zn2+ displacing its bound H2O/HO-. A log-log plot of the dissociation constants for the productive forms of inhibitor plus enzyme versus the acid dissociation constants of the phenolic residues in the inhibitors yields a straight line with a slope of +0.76. This number indicates that the active-site metal ion has special capacity for dispersing negative charge, such as builds up on the oxygen atom of a carboxamide group undergoing nucleophilic addition.

| S-EPMC1132148 | biostudies-other

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