Differentiation between immune checkpoint inhibitor-related and radiation pneumonitis in lung cancer by CT radiomics and machine learning.

ABSTRACT:

Purpose

Consolidation immunotherapy after completion of chemoradiotherapy has become the standard of care for unresectable locally advanced non-small cell lung cancer and can induce potentially severe and life-threatening adverse events, including both immune checkpoint inhibitor-related pneumonitis (CIP) and radiation pneumonitis (RP), which are very challenging for radiologists to diagnose. Differentiating between CIP and RP has significant implications for clinical management such as the treatments for pneumonitis and the decision to continue or restart immunotherapy. The purpose of this study is to differentiate between CIP and RP by a CT radiomics approach.

Methods

We retrospectively collected the CT images and clinical information of patients with pneumonitis who recei

SUBMITTER: Cheng J 

PROVIDER: S-EPMC9306809 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature