Ontology highlight
ABSTRACT: Background
Chronic mucocutaneous candidiasis (CMC) is defined by recurrent or persistent superficial infections involving nails, skin, and/or oral and genital mucosae. IL-17 promotes the recruitment, chemotaxis, and expansion of neutrophils and acts directly on keratinocytes and epithelial cells, driving the production of antimicrobial peptides, essential for the immune response against Candida.Aim
To evaluate the serum level of IL-17 in a family affected by CMC restricted to the nails of the hands and feet.Methods
Serum IL-17 was assayed on 16 patients (aged 21 ± 3.1 years) suffering from persistent onychomycosis caused by Candida and 18 healthy controls (aged 19 ± 2.7 years). Comparisons between groups were performed by Student's unpaired t-test. The level of significance was set at 0.05.Results
The mean serum IL-17 level in patients was 74 ± 1.42 pg/ml, whereas the control group showed a significantly lower level of 25.6 ± 6.7 pg/ml (p < 0.05).Conclusions
We showed a potential defect in the IL-17 signaling pathway in a family affected by CMC restricted to the nails of the hands and feet. Further research is needed to clarify the immunological mechanisms and the genetic etiology at the basis of the unusual clinical presentation in this family.
SUBMITTER: Chimenz R
PROVIDER: S-EPMC9306849 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Chimenz Roberto R Tropeano Angelo A Chirico Valeria V Ceravolo Giorgia G Salpietro Carmelo C Cuppari Caterina C
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20220101
<h4>Background</h4>Chronic mucocutaneous candidiasis (CMC) is defined by recurrent or persistent superficial infections involving nails, skin, and/or oral and genital mucosae. IL-17 promotes the recruitment, chemotaxis, and expansion of neutrophils and acts directly on keratinocytes and epithelial cells, driving the production of antimicrobial peptides, essential for the immune response against Candida.<h4>Aim</h4>To evaluate the serum level of IL-17 in a family affected by CMC restricted to the ...[more]