Ontology highlight
ABSTRACT:
SUBMITTER: Atkinson JR
PROVIDER: S-EPMC9309055 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Atkinson Jeffrey R JR Jerome Andrew D AD Sas Andrew R AR Munie Ashley A Wang Cankun C Ma Anjun A Arnold William D WD Segal Benjamin M BM
JCI insight 20220622 12
Biological aging is the strongest factor associated with the clinical phenotype of multiple sclerosis (MS). Relapsing-remitting MS typically presents in the third or fourth decade, whereas the mean age of presentation of progressive MS (PMS) is 45 years old. Here, we show that experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of encephalitogenic CD4+ Th17 cells, was more severe, and less likely to remit, in middle-aged compared with young adult mice. Donor T cells ...[more]