Ontology highlight
ABSTRACT:
SUBMITTER: Harhala MA
PROVIDER: S-EPMC9312349 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Harhala Marek Adam MA Gembara Katarzyna K Nelson Daniel C DC Miernikiewicz Paulina P Dąbrowska Krystyna K
Antibiotics (Basel, Switzerland) 20220718 7
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated by IgE, we evaluated the general immunogenicity of the highly active antibacterial enzyme, PlyC, in a human population and in a mouse model. The st ...[more]