Ontology highlight
ABSTRACT:
SUBMITTER: McGowan S
PROVIDER: S-EPMC3412044 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
McGowan Sheena S Buckle Ashley M AM Mitchell Michael S MS Hoopes James T JT Gallagher D Travis DT Heselpoth Ryan D RD Shen Yang Y Reboul Cyril F CF Law Ruby H P RH Fischetti Vincent A VA Whisstock James C JC Nelson Daniel C DC
Proceedings of the National Academy of Sciences of the United States of America 20120717 31
Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress from the host. When applied exogenously, these enzymes destroy susceptible microbes and, accordingly, have potential as therapeutic agents. The most potent lysin identified to date is PlyC, an enzyme assembled from two components (PlyCA and PlyCB) that is specific for streptococcal species. Here the structure of the PlyC holoenzyme reveals that a single PlyCA moiety is tethered to a ring-shaped assembly ...[more]