Ontology highlight
ABSTRACT:
SUBMITTER: Maza RM
PROVIDER: S-EPMC9312482 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Maza Rodrigo M RM Barreda-Manso María Asunción MA Reigada David D Silván Ágata Á Muñoz-Galdeano Teresa T Soto Altea A Del Águila Ángela Á Nieto-Díaz Manuel M
Biomedicines 20220630 7
The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes, sensitizing neural cells to noxious stimuli. This study aimed to identify miR-138-5p targets among pro-apoptotic genes overexpressed following SCI and to confirm that miR-138-5p modulates cell death in neural cells. Gene expression and histolog ...[more]