Ontology highlight
ABSTRACT:
SUBMITTER: Rajcsanyi LS
PROVIDER: S-EPMC9314347 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Rajcsanyi Luisa Sophie LS Diebels Inga I Pastoors Lydia L Kanber Deniz D Peters Triinu T Volckmar Anna-Lena AL Zheng Yiran Y Grosse Martin M Dieterich Christoph C Hebebrand Johannes J Kaiser Frank J FJ Horsthemke Bernhard B Hinney Anke A
Scientific reports 20220725 1
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. Analysis of sex-stratified GWAS data revealed that circRNA genomic loci encompassed more genome-wide significant BMI-SNPs in females than in males. To explore whether the enrichment is restricted to BMI ...[more]