Ontology highlight
ABSTRACT:
SUBMITTER: Mazola Y
PROVIDER: S-EPMC9318806 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Mazola Yuliet Y Márquez Montesinos José C E JCE Ramírez David D Zúñiga Leandro L Decher Niels N Ravens Ursula U Yarov-Yarovoy Vladimir V González Wendy W
Pharmaceutics 20220627 7
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels. However, AADs have been limited by proarrhythmic effects, non-cardiovascular toxicities as well as often modest antiarrhythmic efficacy. Theoretical models showed that a combined blockade of Na<sub>v</sub>1.5 (and its current, <i>I<sub>Na</sub></i>) and K<sub>v</sub>1.5 (and its current, <i>I<sub>Kur</sub></i>) ion channels yield a s ...[more]