Ontology highlight
ABSTRACT:
SUBMITTER: Yang M
PROVIDER: S-EPMC6973152 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yang Ming M James Andrew D AD Suman Rakesh R Kasprowicz Richard R Nelson Michaela M O'Toole Peter J PJ Brackenbury William J WJ
Journal of cellular physiology 20191015 4
Ion channels can regulate the plasma membrane potential (V<sub>m</sub> ) and cell migration as a result of altered ion flux. However, the mechanism by which V<sub>m</sub> regulates motility remains unclear. Here, we show that the Na<sub>v</sub> 1.5 sodium channel carries persistent inward Na<sup>+</sup> current which depolarizes the resting V<sub>m</sub> at the timescale of minutes. This Na<sub>v</sub> 1.5-dependent V<sub>m</sub> depolarization increases Rac1 colocalization with phosphatidylseri ...[more]