New Organoselenium (NSAIDs-Selenourea and Isoselenocyanate) Derivatives as Potential Antiproliferative Agents: Synthesis, Biological Evaluation and in Silico Calculations.

ABSTRACT: In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal anti-inflammatory drugs (NSAIDs) scaffolds and Se functionalities (isoselenocyanate and selenourea), which were evaluated against four types of cancer cell line: SW480 (human colon adenocarcinoma cells), HeLa (human cervical cancer cells), A549 (human lung carcinoma cells), MCF-7 (human breast adenocarcinoma cells). Among these compounds, most of the investigated compounds reduced the viability of different cancer cell lines. The most promising compound 6b showed IC₅₀ values under 10 μM against the four cancer cell lines, particularly to HeLa and MCF-7, with IC₅₀ values of 2.3 and 2.5 μM, respectively. Furthermore, two compounds, 6b and 6f, were sel

SUBMITTER: Nie Y 

PROVIDER: S-EPMC9320890 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature