Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC9322363 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Liu Xuan X Yan Shen S Li Mengyuan M Zhang Shengyu S Guo Gang G Yin Quanyi Q Tong Zhenbo Z Chen Xiao Dong XD Wu Winston Duo WD
Pharmaceutics 20220630 7
This work was aimed to develop levodopa (L-dopa) nasal powder to achieve controllable drug release and high nasal deposition efficiency. A series of uniform microparticles, composed of amorphous L-dopa and excipients of hydroxypropyl methyl cellulose (HPMC), polyvinylpyrrolidone (PVP), or hydroxypropyl-β-cyclodextrin (CD), were fabricated by a self-designed micro-fluidic spray dryer. The effects of excipient type and drug/excipient mass ratio on the particle size, morphology, density, and crysta ...[more]