Ontology highlight
ABSTRACT:
SUBMITTER: Mendes A
PROVIDER: S-EPMC9326279 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Mendes Afonso A Heil Hannah S HS Coelho Simao S Leterrier Christophe C Henriques Ricardo R
Open biology 20220727 7
Understanding the structure of supramolecular complexes provides insight into their functional capabilities and how they can be modulated in the context of disease. Super-resolution microscopy (SRM) excels in performing this task by resolving ultrastructural details at the nanoscale with molecular specificity. However, technical limitations, such as underlabelling, preclude its ability to provide complete structures. Single-particle analysis (SPA) overcomes this limitation by combining informati ...[more]