Ontology highlight
ABSTRACT:
SUBMITTER: Farnung L
PROVIDER: S-EPMC9339144 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Farnung Lucas L Vos Seychelle M SM
Current opinion in structural biology 20220217
The first step of eukaryotic gene expression is the assembly of RNA polymerase II and general transcription factors on promoter DNA. This highly regulated process involves ∼80 different proteins that together form the preinitiation complex (PIC). Decades of work have gone into understanding PIC assembly using biochemical and structural approaches. These efforts have yielded significant but partial descriptions of PIC assembly. Over the past few years, cryo-electron microscopy has provided the fi ...[more]