Ontology highlight
ABSTRACT:
SUBMITTER: Grunberg S
PROVIDER: S-EPMC3843768 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Grünberg Sebastian S Hahn Steven S
Trends in biochemical sciences 20131011 12
Transcriptional regulation is one of the most important steps in control of cell identity, growth, differentiation, and development. Many signaling pathways controlling these processes ultimately target the core transcription machinery that, for protein coding genes, consists of RNA polymerase II (Pol II) and the general transcription factors (GTFs). New studies on the structure and mechanism of the core assembly and how it interfaces with promoter DNA and coactivator complexes have given tremen ...[more]