Influence of gonadal steroids on cortical surface area in infancy.
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ABSTRACT:
SUBMITTER: Alex AM
PROVIDER: S-EPMC9340392 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Influence of gonadal steroids on cortical surface area in infancy.
Alex Ann Mary AM Ruvio Tom T Xia Kai K Jha Shaili C SC Girault Jessica B JB Wang Li L Li Gang G Shen Dinggang D Cornea Emil E Styner Martin A MA Gilmore John H JH Knickmeyer Rebecca C RC
Cerebral cortex (New York, N.Y. : 1991) 20220701 15
Sex differences in the human brain emerge as early as mid-gestation and have been linked to sex hormones, particularly testosterone. Here, we analyzed the influence of markers of early sex hormone exposure (polygenic risk score (PRS) for testosterone, salivary testosterone, number of CAG repeats, digit ratios, and PRS for estradiol) on the growth pattern of cortical surface area in a longitudinal cohort of 722 infants. We found PRS for testosterone and right-hand digit ratio to be significantly ...[more]
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