Dataset Information

Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.

ABSTRACT:

Study design

To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG)-positron emission tomography (PET).

Methods

We prospectively enrolled 20 PLWH and 20 uninfected people with no known cardiovascular disease and at least 3 traditional cardiovascular risk factors. All patients underwent ¹⁸F-FDG-PET/computed tomography (CT) of the thorax and neck. Biomarkers linked to inflammation and atherosclerosis were also determined. The primary outcome was AI in ascending aorta (AA) measured as mean maximum target-to-background ratio (TBR_max). The independent relationships between HIV status and both TBR_max and biomarkers were evaluated by multivariable linear regression adjusted for body mass index, creatinine, statin therapy, and atherosclerotic cardiovascular 10-year estimated risk (ASCVD).

Results

Unadjusted mean TBR_max in AA was slightly higher but not statistically different (P = .18) in PLWH (2.07; IQR 1.97, 2.32]) than uninfected people (2.01; IQR 1.85, 2.16]). On multivariable analysis, PLWH had an independent risk of increased mean log-TBR_max in AA (coef = 0.12; 95%CI 0.01,0.22; P = .032). HIV infection was independently associated with higher values of interleukin-10 (coef = 0.83; 95%CI 0.34, 1.32; P = .001), interferon-γ (coef. = 0.90; 95%CI 0.32, 1.47; P = .003), and vascular cell adhesion molecule-1 (VCAM-1) (coef. = 0.75; 95%CI: 0.42, 1.08, P < .001).

Conclusions

In patients with high cardiovascular risk, HIV status was an independent predictor of increased TBR_max in AA. PLWH also had an increased independent risk of IFN-γ, IL-10, and VCAM-1 levels.

SUBMITTER: Taglieri N

PROVIDER: S-EPMC9345795 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.

Taglieri Nevio N Bonfiglioli Rachele R Bon Isabella I Malosso Pietro P Corovic Andrej A Bruno Matteo M Le Elizabeth E Granozzi Bianca B Palmerini Tullio T Ghetti Gabriele G Tamburello Martina M Bruno Antonio Giulio AG Saia Francesco F Tarkin Jason M JM Rudd James H F JHF Calza Leonardo L Fanti Stefano S Re Maria Carla MC Galié Nazzareno N

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20210210 4

<h4>Study design</h4>To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG)-positron emission tomography (PET).<h4>Methods</h4>We prospectively enrolled 20 PLWH and 20 uninfected people with no known cardiovascular disease and at least 3 traditional cardiovascular risk factors. All patients underwent <sup>18</sup>F-FDG-PET/computed tomography (CT) of the thorax and neck. Biomarkers li ...[more]

PMID: 33569752

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Project description:BackgroundIn sub-Saharan Africa, there is paucity of research on substance use patterns among young people living with HIV (YLWH). To address the gap, we sought to: i) determine the prevalence of substance use, specifically alcohol and illicit drug use, among YLWH compared to their HIV-uninfected peers; ii) investigate the independent association between young people's HIV infection status and substance use; iii) investigate the risk indicators for substance use among these young people.MethodsBetween November 2018 and September 2019, a cross-sectional study was conducted at the Kenyan coast recruiting 819 young people aged 18-24 years (407 HIV-positive). Alcohol and drug use disorders identification tests (AUDIT and DUDIT) were administered via audio computer-assisted self-interview alongside other measures. Logistic regression was used to determine substance use risk indicators.ResultsThe point prevalence of current substance use was significantly lower among YLWH than HIV-uninfected youths: current alcohol use, 13% vs. 24%, p < 0.01; current illicit drug use, 7% vs. 15%, p < 0.01; current alcohol and illicit drug use comorbidity, 4 vs. 11%, p < 0.01. Past-year prevalence estimates for hazardous substance use were generally low among young people in this setting (< 10%) with no significant group differences observed. Being HIV-positive independently predicted lower odds of current substance use, but not hazardous substance use. There was overlap of some risk indicators for current substance use between young people with and without HIV including male sex, khat use and an experience of multiple negative life events, but risk indicators unique to either group were also identified. Among YLWH, none of the HIV-related factors was significantly associated with current substance use.ConclusionsAt the Kenyan coast, substance use is a reality among young people. The frequency of use generally appears to be low among YLWH compared to the HIV-uninfected peers. Substance use prevention initiatives targeting young people, regardless of HIV infection status, are warranted in this setting to avert their potential risk for developing substance use disorders, including dependence. The multifaceted intrapersonal and interpersonal factors that place young people at risk of substance use need to be addressed as part of the substance use awareness and prevention initiatives.

Dataset Information

Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.

Study design

Methods

Results

Conclusions

Publications

Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.

Similar Datasets

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