Dataset Information

Molecular characterisation of Neisseria gonorrhoeae associated with disseminated gonococcal infections in Queensland, Australia: a retrospective surveillance study.

ABSTRACT:

Objectives

Gonorrhoea caused by Neisseria gonorrhoeae is the second most notified sexually transmitted infection (STI) in Australia and the case numbers for this STI have been increasing globally. Progressive gonococcal infection may lead to disseminated gonococcal infection (DGI), which causes significant morbidity among patients. This study aims to examine the genetic diversity of N. gonorrhoeae isolates collected in Queensland from January 2010 to August 2015 and to determine factors associated with DGI in Queensland.

Design

Retrospective surveillance study for epidemiological purposes.

Setting

All gonorrhoeae isolates referred by private and public pathology laboratories to the state of Queensland, Australia Neisseria reference laboratory.

Methods

Between January 2010 and August 2015, 3953 N. gonorrhoeae isolates from both metropolitan and regional Queensland infections were typed with NG-MAST (N. gonorrhoeae multiantigen sequence typing) to assess the genetic diversity between strains. Whole-genome sequencing (WGS) was used to investigate strain-related factors associated with DGI.

Results

ST6876 was the most common NG-MAST type, detected in 7.6% of the isolates. DGI was significantly more likely in females <30 years (OR 13.02, p<0.0001) and in older males >30 years (OR 6.04, p<0.0001), with most cases originating from North Queensland (OR 8.5, p<0.0001). Strains harbouring PIA class of porB type were associated with DGI (OR 33.23, p<0.0001).

Conclusion

Genotyping techniques, such as NG-MAST and WGS, are proving instrumental in providing an insight into the population structure of N. gonorrhoeae, and genetic mechanisms of pathogenesis, such as for DGI.

SUBMITTER: Guglielmino CJD

PROVIDER: S-EPMC9351343 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Molecular characterisation of <i>Neisseria gonorrhoeae</i> associated with disseminated gonococcal infections in Queensland, Australia: a retrospective surveillance study.

Guglielmino Christine J D CJD Sandhu Sumeet S Lau Colleen L CL Buckely Cameron C Trembizki Ella E Whiley David M DM Jennison Amy V AV

BMJ open 20220802 8

<h4>Objectives</h4>Gonorrhoea caused by <i>Neisseria gonorrhoeae</i> is the second most notified sexually transmitted infection (STI) in Australia and the case numbers for this STI have been increasing globally. Progressive gonococcal infection may lead to disseminated gonococcal infection (DGI), which causes significant morbidity among patients. This study aims to examine the genetic diversity of <i>N. gonorrhoeae</i> isolates collected in Queensland from January 2010 to August 2015 and to dete ...[more]

PMID: 35918119

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