Dataset Information

Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.

ABSTRACT:

Background

mixed evidence exists on the association between muscle strength and mortality in older adults, in particular for cancer mortality.

Aim

to examine the dose-response association of objectively handgrip strength with all-cause and cancer mortality.

Study design and setting

data from consecutive waves from the Survey of Health, Ageing and Retirement in Europe comprising 27 European countries and Israel were retrieved. Overall, 54,807 men (45.2%; 128,753 observations) and 66,576 women (54.8%; 159,591 observations) aged 64.0 (SD 9.6) and 63.9 (SD 10.2) years, respectively, were included. Cox regression and Fine-Grey sub-distribution method were conducted.

Results

during the follow-up period (896,836 person-year), the fully adjusted model showed the lowest significant risk estimates for the highest third of handgrip strength when compared with the first third (reference) in men (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.34-0.50) and women (HR, 0.38; 95% CI, 0.30-0.49) for all-cause mortality. We identified a maximal threshold for reducing the risk of all-cause mortality for men (42 kg) and women (25 kg), as well as a linear dose-response association in participants aged 65 or over. No robust association for cancer mortality was observed.

Conclusion

these results indicate an inverse dose-response association between incremental levels of handgrip and all-cause mortality in older adults up to 42 kg for men and 25 kg for women, and a full linear association for participants aged 65 years or over. These findings warrant preventive strategies for older adults with low levels of handgrip strength.

SUBMITTER: Lopez-Bueno R

PROVIDER: S-EPMC9351371 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.

López-Bueno Rubén R Andersen Lars Louis LL Calatayud Joaquín J Casaña José J Grabovac Igor I Oberndorfer Moritz M Del Pozo Cruz Borja B

Age and ageing 20220501 5

<h4>Background</h4>mixed evidence exists on the association between muscle strength and mortality in older adults, in particular for cancer mortality.<h4>Aim</h4>to examine the dose-response association of objectively handgrip strength with all-cause and cancer mortality.<h4>Study design and setting</h4>data from consecutive waves from the Survey of Health, Ageing and Retirement in Europe comprising 27 European countries and Israel were retrieved. Overall, 54,807 men (45.2%; 128,753 observations ...[more]

PMID: 35639798

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Project description:BackgroundAgeing is associated with a gradual loss of muscle strength, which in the end may have consequences for survival. Whether muscle strength and mortality risk associate in a gradual or threshold-specific manner remains unclear. This study investigates the prospective association of muscle strength with all-cause mortality in the oldest old.MethodsWe included 1890 adults aged ≥ 90 years (61.6% women, mean age 91.0 ± 1.5 years) from 27 European countries and Israel participating in the Survey of Health, Ageing and Retirement in Europe (SHARE) study. Muscle strength was assessed using handgrip dynamometry (unit: kilogram). Using time-varying Cox regression with restricted cubic splines, we determined the prospective association of muscle strength with mortality, controlling for age, sex, smoking, BMI, marital status, education, geographical region and self-perceived health.ResultsOver a mean follow-up of 4.2 ± 2.4 years, more than half of the participants died (n = 971, 51.4%). The mean handgrip strength was 20.4 ± 8.0 kg for all participants, with men (26.7 ± 7.5 kg) showing significantly higher strength than women (16.4 ± 5.4 kg) (p < 0.001). Using the median level of muscle strength as reference (18 kg), lower and higher levels were associated in a gradual and curvilinear fashion with higher and lower mortality risk, respectively. The 10th percentile of muscle strength (10 kg) showed a hazard ratio (HR) of 1.27 (95% CI 1.13-1.43, p < 0.001). The 90th percentile (31 kg) showed an HR of 0.69 (95% CI 0.58-0.82, p < 0.001). Stratified for sex, the median levels of muscle strength were 26 kg for men and 16 kg for women. The 10th percentile of muscle strength showed HRs of 1.33 (95% CI 1.10-1.61, p < 0.001) at 15 kg for men and 1.19 (95% CI 1.05-1.35, p < 0.01) at 10 kg for women. The 90th percentile of muscle strength showed HRs of 0.75 (95% CI 0.59-0.95, p < 0.01) at 35 kg for men and 0.75 (95% CI 0.62-0.90, p < 0.001) at 23 kg for women. Sensitivity analyses, which excluded individuals who died within the first 2 years of follow-up, confirmed the main findings.ConclusionRather than a specific threshold, muscle strength is gradually and inversely associated with mortality risk in the oldest old. As muscle strength at all ages is highly adaptive to resistance training, these findings highlight the importance of improving muscle strength in both men and women among the oldest old.

Dataset Information

Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.

Background

Aim

Study design and setting

Results

Conclusion

Publications

Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.

Similar Datasets

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