Dataset Information

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study.

ABSTRACT:

Background

The characterization of reinfection with SARS-CoV-2 has been a subject of concern and controversy, especially with the surge of infections with highly transmissible variants worldwide.

Methods

This retrospective national study used comorbidities, vaccination status, SARS-CoV-2 variants of concern, and demographics data to profile participants who were reinfected with SARS-CoV-2, defined as having two reverse transcriptase-polymerase chain reaction-positive SARS-CoV-2 tests within at least 90 days apart. A multivariate logistic regression model assessed the risk factors associated with reinfection . Two control groups were selected: nonreinfected participants reporting a positive test (control group one) and those reporting a negative test (control group two).

Results

Between March 2020 and December 2021, 4454 reinfected participants were identified in Saudi Arabia (0.8%, 95% confidence interval [CI] 0.7-0.8). The majority (67.3%) were unvaccinated (95% CI 65.9-68.7) and 0.8% (95% CI 0.6-1.1) had severe or fatal SARS-CoV-2 disease. COVID-19 vaccines were 100% effective against mortality in reinfected individuals who received at least one dose, whereas it conferred 61% (odds ratio [OR] 0.4, 95% CI 0.1-1.0) additional protection against severe disease after the first dose and 100% after the second dose. In the risk factor analysis, reinfection was highly associated with comorbidities, such as HIV (OR 2.5, 95% CI 1.3-5.2; P = 0.009), obesity (OR 2.3, 95% CI 1.3-3.9; P = 0.003), pregnancy (OR 3.2, 95% CI 1.4-7.4; P = 0.005), and working in health care facilities (OR 6.1, 95% CI 3.1-12.9; P <0.0001). The delta variant (B.1.617.2) was the most frequent variant of concern among the reinfected cohort.

Conclusion

This in-depth study of the reinfection profile identified risk factors and highlighted the associated SARS-CoV-2 variants. Results showed that naturally acquired immunity to SARS-CoV-2 through multiple reinfections together with vaccine-induced immunity provided substantial protection against severe SARS-CoV-2 disease and mortality.

SUBMITTER: Al-Otaiby M

PROVIDER: S-EPMC9364818 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study.

Al-Otaiby Maram M Krissaane Ines I Al Seraihi Ahad A Alshenaifi Jumanah J Qahtani Mohammad Hassan MH Aljeri Thamer T Zaatari Ezzedine E Hassanain Mazen M Algwizani Abdullah A Albarrag Ahmed A Al-Mozaini Maha M Alabdulaali Mohammed M

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20220714

<h4>Background</h4>The characterization of reinfection with SARS-CoV-2 has been a subject of concern and controversy, especially with the surge of infections with highly transmissible variants worldwide.<h4>Methods</h4>This retrospective national study used comorbidities, vaccination status, SARS-CoV-2 variants of concern, and demographics data to profile participants who were reinfected with SARS-CoV-2, defined as having two reverse transcriptase-polymerase chain reaction-positive SARS-CoV-2 te ...[more]

PMID: 35840098

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Project description:BackgroundEstimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients.MethodsA total of 11,703 serum samples were collected from different regions of the KSA including; 5395 samples from residual healthy blood donors (D); 5877 samples from non-COVID patients collected through residual sera at clinical biochemistry labs from non-COVID patients (P); and 400 samples from consented HCWs. To determine the seroprevalence of SARS-CoV-2, all serum samples, in addition to positive control sera from RT-PCR confirmed COVID-19 patients, were subjected to in-house ELISA with a sample pooling strategy, which was further validated by testing individual samples that make up some of the pools, with a statistical estimation method to report seroprevalence estimates.ResultsOverall (combining D and P groups) seroprevalence estimate was around 11% in Saudi Arabia; and was 5.1% (Riyadh), 1.5% (Jazan), 18.4% (Qassim), 20.8% (Hail), 14.7% (ER; Alahsa), and 18.8% in Makkah. Makkah samples were only D group and had a rate of 24.4% and 12.8% in the cities of Makkah and Jeddah, respectively. The seroprevalence in Saudi Arabia across the sampled areas would be 12 times the reported COVID-19 infection rate. Among HCWs, 7.5% (4.95-10.16 CI 95%) had reactive antibodies to SARS-CoV-2 without reporting any previously confirmed infection. This was higher in HCWs with hypertension. The study also presents the demographics and prevalence of co-morbidities in HCWs and subset of non-COVID-19 population.InterpretationOur study estimates the overall national serological prevalence of COVID-19 in Saudi Arabia to be 11%, with an apparent disparity between regions. This indicates the prevalence of asymptomatic or mild unreported COVID-19 cases.

Project description:BackgroundDue to the recent evolution of telecommunications, it is now acknowledged that digital communication provides essential services for remote areas. Teleradiology allows the ability to obtain images at one site, send them over a distance, and view them remotely for diagnostic or consultation purposes.AimThe highlighted objectives include (a) the added value of the service, (b) user satisfaction, and (c) quality assurance according to global best practices and national quality standards.MethodsThis study utilised an eight-part online self-report survey distributed among employees of the Ministry of Health (MOH) who use the national teleradiology platform. The survey sections were designed to gather comprehensive data, including participant demographics, levels of satisfaction with the service, awareness of security measures, communication effectiveness, perceived advantages and disadvantages, quality assurance, technical challenges, IT support, and future perceptions of teleradiology services. Additionally, a total of 212 MRI reports from patients who underwent brain and spine MRI examinations between 2018 and 2020 were collected from the platform to strengthen the analysis.ResultsMost survey respondents (78%) were males, with a significant majority (96.2%) affirming that teleradiology sufficiently addresses clinical inquiries. Furthermore, 90% expressed satisfaction with the service, and 93% endorsed the standardization of MR imaging procedures across Ministry of Health (MOH) hospitals. Notably, 92.4% recognised teleradiology as a transformative strategy for healthcare facilities in Saudi Arabia, concurring with its benefits. The analysis of the MRI reports revealed structural inconsistencies; compared with structured templates, the average number of incorporated elements was reduced, and essential elements were frequently absent. Intriguingly, reports delineating normal cases included a higher incidence of clinical impressions relative to those describing abnormalities, yet the latter contained a more comprehensive array of elements. Variability in report composition was correlated with the years of experience of the reporters. Teleradiology users perceived enhancements in the quality of radiological reporting and the daily operational workflow. Nonetheless, certain limitations were identified, necessitating focused improvements by service providers.ConclusionDespite teleradiology being a subspecialisation, it can reduce the role of local radiologists. Further research is needed on data security, confidentiality, and archiving options, as well as the cost-effectiveness of teleradiology services.

Dataset Information

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study.

Background

Methods

Results

Conclusion

Publications

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study.

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