New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity.

ABSTRACT: Laetiporus sulphureus is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A-D (1-4), along with 12 known analogues, were isolated from the fruits of L. sulphureus. Nuclear magnetic resonance, infrared spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques were used for the investigation of the chemical structure of isolated compounds. In addition, the anti-inflammatory activity of three new compounds (2-4) was tested for NO production in lipopolysaccharide-induced RAW 264.7 cells. The IC₅₀ values of isolated triterpenoids ranged from 14.3 to 42.3 μM, which were more effective than the positive control (IC₅₀ for minocycline was 73.0 μM). The experimentally obtained anti-inflammatory activity data of L. sulphureus are in agreement with its traditional use.

SUBMITTER: Khalilov Q 

PROVIDER: S-EPMC9366770 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature