Ontology highlight
ABSTRACT:
SUBMITTER: Domenech-Sanchez A
PROVIDER: S-EPMC93711 | biostudies-literature | 1999 May
REPOSITORIES: biostudies-literature
Doménech-Sánchez A A Hernández-Allés S S Martínez-Martínez L L Benedí V J VJ Albertí S S
Journal of bacteriology 19990501 9
Klebsiella pneumoniae porin genes were analyzed to detect mutations accounting for the porin deficiency observed in many beta-lactam-resistant strains. PCR and Southern blot analysis revealed the existence of a third porin gene in addition to the OmpK36 and OmpK35 porin genes previously described. This new porin gene was designated ompK37 and is present in all of the clinical isolates tested. The OmpK37 porin gene was cloned, sequenced, and overexpressed in Escherichia coli. In contrast to that ...[more]