Ontology highlight
ABSTRACT:
SUBMITTER: Day M
PROVIDER: S-EPMC9371934 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Day Matthew M Oliver Antony W AW Pearl Laurence H LH
Nucleic acids research 20220801 14
The RAD9-RAD1-HUS1 (9-1-1) clamp forms one half of the DNA damage checkpoint system that signals the presence of substantial regions of single-stranded DNA arising from replication fork collapse or resection of DNA double strand breaks. Loaded at the 5'-recessed end of a dsDNA-ssDNA junction by the RAD17-RFC clamp loader complex, the phosphorylated C-terminal tail of the RAD9 subunit of 9-1-1 engages with the mediator scaffold TOPBP1 which in turn activates the ATR kinase, localised through the ...[more]